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1、Cancer Proteomics: From Bench to Bedside

Publisher: Humana Press | Language: English | ISBN:1588298582 | 300 pages | Data: 2007 | PDF | 3.5 Mb

Description: This book provides the reader with broad perspectives and breadth of knowledge on current topics related to the use of proteomic strategies in cancer therapy as well as anticipated challenges that may arise from its application in daily practice. The book is divided into 4 parts. The first part begins with the current technologies used in proteomics that allow for protein profiling and for the identification of druggable targets in human samples. Mass spectrometry based protein characterization and protein microarrays hold great promise of predicting response to specific drugs in cancer therapy. The second part deals with the use proteomics in cell signaling. At the present, the pharmaceutical and biotechnology industries have many potentially useful small molecule inhibitors of many pathways important in cancer that have yet to be taken to clinical trials. Understanding protein-protein interaction and posttranslational modifications through proteomics will likely make it much more feasible to do effective clinical trials of these small molecules alone and in combinations to overcome drug resistance and improve patient care. The third part of the book moves from signaling to actual clinical applications of proteomics in cancer therapy. Case studies in may tumor types are provided to show the feasibility of generating the critical information needed to individualization of therapy in cancer patients. The final part of the book provides in depth information on annotating the human proteome and the role of Food and Drug Administration (FDA) in regulating the use of proteomics in cancer therapy. To functionally annotate the human proteome, the Swiss Institute for Bioinformatics (SIB) and the European Bioinformatics Institute (EBI) initiated a major effort to distribute to the scientific community highly integrated information on human protein sequences. This initiative, which is called the Human Proteomics Initiative (HPI) aims to provide for each known human protein a wealth of information that include the description of its function, domain and protein family classification, subcellular location, posttranslational modifications, variants and similarities to other proteins. Integration of bioinformatics into clinical application of proteomics in cancer therapy is outlined as well as regulations and policy of commercial application of proteomics in patient care.

2、Introduction to Proteomics: Tools for the New Biology

Humana Press | ISBN 0896039919 | 2001 | PDF | 198 pages | 3.0 MB

Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein–protein interactions and networks.

3、Mass Spectometry Data Analysis in Proteomics (Methods in Molecular Biology, Vol 367)

Humana Press | 1158829563X | Edition - 2007 | PDF | 320 pages | 3.753 MB | Rapidshare & Megaupload

Mass Spectrometry Data Analysis in Proteomics is an in-depth guide to the theory and practice of analyzing raw mass spectrometry (MS) data in proteomics. As MS is a high throughput technique, proteomic researchers must attend carefully to the associated field of data analysis, and this volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. General guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided, with specific attention to identifying poor quality data and optimizing search parameters. Several different types of MS data are discussed, followed by a description of optimal methods for conversion of raw data into peak lists for input to search engines. Choosing the most accurate and complete databases is emphasized, and a report of available sequence databases is included. Methods for assembling expressed sequence tags (ESTs) into assembled nonredundant databases are provided, along with protocols for further processing the sequences into a format suitable for MS data. Mass Spectrometry Data Analysis in Proteomics describes publicly available applications whenever possible.

4、Mass Spectrometry in Cancer Research

CRC | 2002 | ISBN: 084930167X | Pages: 576 | PDF | 6.66 MB

Covering principles and techniques of mass spectrometry, this book also discusses relevant concepts of cancer medicine and biology. Mass Spectrometry in Cancer Research details the identification, metabolism and dosimetry of carcinogens as well as the pharmacokinetics and metabolism of antineoplastic agents. This book also examines techniques and applications in cancer biochemistry and biology and offers approximately 240 figures and 30 tables illustrating the concepts in the text. Some topics include principles and techniques of mass spectrometry; identification, metabolism and dosimetry of carcinogens; and techniques and applications in cancer biochemistry and biology

5、Separation Methods In Proteomics by: John Piro (Author), Gary B. Smejkal (Editor), Alexander Lazarev (Editor)

Publisher: CRC Press | 12 Dec 2005 | ISBN: 0824726995 | Pages: 536 | PDF | 7.38 MB

Separation Methods in Proteomics provides a comprehensive examination of all major separation techniques for proteomics research. The editors take a broad survey of the field, avoiding bias to any particular method. Coverage extends across the entire process, from sample preparation to clinical and research applications such as drug and biomarker discovery. The book provides detailed discussions on prefractionation methods, electrophoresis, high performance liquid chromatography (HPLC), and NMR techniques, among others. Demonstrating applications to clinical and basic research, the text is ideal for scientists in proteomics, genomics, transcriptomics, biomarker discovery, and drug discovery.

6、Proteome Research: Concepts, Technology and Application

Publisher: Springer; 2nd ed. edition
Language: english
ISBN: 3540712402
Paperback: 210 pages
Data: September 2007
Format: PDF
Description: Proteomics is a multifaceted, interdisciplinary field which studies the complexity and dynamics of proteins in biological systems. It combines powerful separation and analytical technology with advanced informatics to understand the function of proteins in the cell and in the body. This book provides a clear conceptual description of each facet of proteomics, describes recent advances in technology and thinking in each area, and provides details of how these have been applied to a variety of biological problems. It is written by expert practitioners in the field, from industry, research institutions, and the clinic. It provides junior and experienced researchers with an invaluable proteomic reference, and gives fascinating glimpses of the future of this dynamic field.

7、"Proteomics in Drug Research"

Wiley-VCH; 1 edition (May 1, 2006) | ISBN:3527312269 | 383 page | PDF | 3,2 Mb

From skillful handling of the wide range of technologies to successful applications in drug discovery—this handbook has all the information professional proteomics users need.

Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.

Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.

Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

8、Tissue Proteomics: Pathways, Biomarkers, and Drug Discovery (Methods in Molecular Biology) By Brian Liu

Publisher Humana Press | ISBN: 1588296792 | edition 2008 | PDF | 300 pages | 2,18 mb

With the completion of human genome sequencing, the field of proteomics has grown vital to biomedical research. Among the array of protocols developed to study the human proteome, many protocols examine proteins derived specifically from cell lines, body fluids or human tissues - not necessarily compatible with the full range of protein sources commonly used in the laboratory

9、Proteomics in Practice: A Laboratory Manual of Proteome Analysis

Wiley-VCH | ISBN: 3527303545 | 2002 | 342 pages | PDF or DjVu | 10.4 MB or 2.1 MB

A combined review, manual and reference for the successful analysis of proteins using the classical approach of 2-D gel electrophoresis, mass spectrometry and related sequence database inquiries.
The first section, written in a textbook style, introduces the entire technology, while the second section represents a comprehensive laboratory manual spanning the full range of methods from sample preparation to protein identification. Alternative methods and procedures are only suggested for those cases where the "default" procedure would fail to deliver adequate results. The third section is a unique troubleshooting guide, designed to answer many of the frequently asked questions regarding proteome analysis. The final section contains a thorough reference list to guide interested readers towards further detail.
Intended for all those wishing to go beyond the theoretical aspects of proteome analysis, this book is targeted at research groups within academia and industry, course instructors, research assistants and graduate students.

10、Clinical Proteomics: Methods and Protocols (Methods in Molecular Biology) By Antonia Vlahou

Publisher: Humana Press | 18-01-2008 | ISBN: 158829837X | 408 pages | 4.38 Mb

The field of clinical proteomics has rapidly evolved during the past few years and is continuously growing as new methodologies and technologies emerge. In Clinical Proteomics, a select group of leading researchers has contributed their state-of-the-art methodologies on protein profiling and identification of disease biomarkers in tissues, microdissected cells and body fluids. Experimental approaches involving the application of two-dimensional electrophoresis, multi-dimensional liquid chromatography, SELDI/MALDI mass spectrometry and protein arrays, as well as the bioinformatic and statistical tools pertinent to the analysis of proteomics data, are thoroughly detailed in these readily reproducible methods and protocols, explained through the step-by-step instructional format of the highly successful Methods in Molecular Biology series.

11、Peptidomics: Methods and Applications

Publisher: Wiley-Interscience | 2007-12-14 | 401 pages | ISBN: 0471677817 | 4.5 MB | PDF | Rapidshare&Megaupload

This book describes the methods of peptidomics for the study of proteins, how it works, and applications in areas from drug discovery to toxicity biomarker analysis. The book provides information that is both sufficiently detailed to be a step-by-step guide for beginning researchers, while also being a reference for experienced professionals. The book explains the current state of the field, new developments now emerging, and examples of applications for in fields from pharmaceutical science, to toxicity biomarkers, to neuroscience.

12、Proteomics in Practice: A Guide to Successful Experimental Design

Publisher: Wiley-VCH | ISBN: 3527319417 | edition 2008 | PDF | 502 pages | 5,6 mb

A combined review, manual and reference for the successful analysis of proteins using the classical approach of 2-D gel electrophoresis, mass spectrometry and related sequence database inquiries. The first section, written in a textbook style, introduces the entire technology, while the second section represents a comprehensive laboratory manual spanning the full range of methods from sample preparation to protein identification. Alternative methods and procedures are only suggested for those cases where the "default" procedure would fail to deliver adequate results.

13、 “Membrane Proteomics: Methods and Protocols”

Humana Press | 2009-02-03 | ISBN: 1603273093 | 318 pages | PDF | 3,75 MB

With the great cellular and therapeutic importance of plasma membrane proteins, unbiased technologies such as proteomics become even more vital as they have the power to define patterns of membrane protein expression characteristic of distinct states of cellular development, differentiation or disease, and thereby identify novel markers of, or targets for intervention in, disease. In Membrane Proteomics: Methods and Protocols, leading experts in the field compile a laboratory bench resource which provides a comprehensive toolkit of proven methods. The volume delves into various modifications to standard two-dimensional gel electrophoresis protocols as well as liquid chromatographic methods, protocols for the enrichment of diverse classes of plasma membrane proteins, in silico approaches, and cutting-edge techniques for quantitative membrane protein profiling. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Comprehensive and easy-to-use, Membrane Proteomics: Methods and Protocols is an ideal guide for investigators wishing to apply state of the art membrane proteomic methodologies in their own research programs.

14、“Mass Spectrometry of Proteins and Peptides: Methods and Protocols”

Humana Press | 2008 | ISBN: 1934115487 | 474 pages | PDF | 7,4 MB

When the last edition of this book was published in 2000, the field of proteomics was in its infancy. Now in its adolescence, proteomics is fundamentally transforming biological and medical research. Much of this transformation can be attributed to technological advancements, particularly in mass spectrometry. As a result of these rapid developments that have led to expanded areas of research and innovative applications, an update to Mass Spectrometry of Proteins and Peptides is not only worthwhile, but arguably mandatory. Spanning fields from microbial forensics and clinical applications to protein structure, dynamics and function, the following chapters written by leading experts serve as a forum for presenting some of the latest revolutionizing methods for mass spectrometry-based characterization of proteins and peptides. Staying faithful to the spirit of the Methods in Molecular Biology™ series, all chapters are written in the same format, whereby each chapter opens with a basic description of the method, followed by a description of the protocol and then practical step-by-step instructions to ensure experimental success.

Mass Spectrometry of Proteins and Peptides: Methods and Protocols, Second Edition

is a valuable resource for novice and seasoned practitioners in the fields of biochemistry, molecular biology, clinical chemistry, immunology, genetic, microbiology and toxicology

15、2D PAGE: Sample Preparation and Fractionation: Volume 1 (Methods in Molecular Biology Volume 424)

Publisher: Humana Press | 2008-03-14 | 554 pages | ISBN:1588297225 | 7.53 MB

This book presents a broad coverage of the principles and recent developments of sample preparation and fractionation tools in Expression Proteomics in general and for two-dimensional electrophoresis (2-DE) in particular. 2-DE, with its unique capacity to resolve thousands of proteins in a single run, is still a fundamental research tool for nearly all protein-related scientific projects. The methods described here in detail are not limited to 2-DE and can also be applied to other protein separation techniques

16、2D PAGE: Sample Preparation and Fractionation: Volume 2 (Methods in Molecular Biology Volume 425)

Publisher: Humana Press | 2008-03-14 | 455 pages | ISBN: 1603272097 | 4.2 MB | Rapidshare&Megaupload

This book presents a broad coverage of the principles and recent developments of sample preparation and fractionation tools in Expression Proteomics in general and for two-dimensional electrophoresis (2-DE) in particular. 2-DE, with its unique capacity to resolve thousands of proteins in a single run, is still a fundamental research tool for nearly all protein-related scientific projects. The methods described here in detail are not limited to 2-DE and can also be applied to other protein separation techniques

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